Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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The exact mechanism through which the explored extracts act on each tumor cell line is obviously difficult to highlight. These plants are widely used in the Moroccan traditional folk medicine.

The species within this genus can vary extensively in their habitleaf divisioninvolucrereceptacle and achenes. After 24 h incubation, cells were then treated with the essential oil of Cotula cinerea or its extracts cineres, ethyl acetate, and n -butanol in addition to those of Salvia verbenaca.

Retrieved from ” https: The obtained findings for the two cell lines RD and Vero are summarized in Figures 1 and 2respectively. Indeed, the antitumor properties of phenolic compounds and cinersa against several cell lines representing numerous human cell lines have been previously coyula [ 6 ]. Cotula vulgaris Levyns Cotula zeyheri Fenzl. However, and despite all the progress made, the cancer treatment remains a challenging task for both the patients and the medical staff.

Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc. The three extracts hexane, ethyl acetate, and n-butanol of each plant in addition to the essential oil of Cotula cinerea have then been assayed for their cytotoxic activity against RD and Vero cell lines using MTT assay. Huile essentielle de Ctula africana Jord.

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Indexed in Science Citation Index Expanded. The tentative global mechanism gathered probably all these actions which are thus supposed to provide the observed cytotoxic effect.

Cotula macroglossa Bolus ex Schltr. Results and Discussion In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca. The evaluation of cell viability has been achieved through cinedea use of MTT 3- 4,5-dimethylthiazol-2,5-diphenyl tetrazolium bromide assay.


The collected aerial parts were left under shade at room temperature until complete drying. However, and despite the widespread use of these plants in Moroccan traditional folk medicine, to the best of our knowledge, no information has been previously reported on the anticancer activity of Moroccan Cotula cinerea and Salvia verbenaca.

Lloyd has proposed that the five species from Australia and New Guinea are distinctive enough from the other species from the section Cptula to be brought under a new section with the proposed name Oligoleima type species C. Due to its complex phytochemical composition, it is difficult to define a unique mechanism of its action on the used cell tumor. These two species were obtained from the National Institute of Health, Rabat, Morocco, and were cultivated as previously described by Aneb et al.

The biological activity of C. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. In the genus was subdivided by George Bentham [5] into three sections. These compounds could explain the cytotoxic effect of this extract on RD tumor cell line. The current widely used cancer treatments such as surgery, radiotherapy, systemic therapy, and chemotherapy are very expensive and cause cotyla side and adverse effects [ 4 ].

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Material and Methods 2. The genus can only be defined by looking at the corollas of their flowers.

Sports Turf Research Institute. Introduction Cancer is a complex disease caused by several factors such as genetic deregulation, environmental influencing agents, clnerea epigenetic modification factors [ 12 ]. This genus was first mentioned by Carl Linnaeuswho described four species clnerea his first edition of Species Plantarum.

The main constituents of the essential oil are Camphor, Camphene, Alpha-pinene, 3-carene, Thujone, 4-terpineol, Z -betafarnesene and santolinatriene. In this work we were interested in exploring the potential cytotoxicological effect of Cotula cinerea and Salvia verbenaca from Morocco.

Salvia verbenaca is a Mediterranean plant currently belonging to the Lamiaceae family.

Cotula – Wikipedia

The obtained values are correlated with the metabolized intracellular MTT concentrations and are therefore proportional to the number of living cells. Abstract The objective of this work was to investigate the cytotoxicological effect of the extracts hexane, ethyl acetate, and n -butanol of Cotula cinerea and Salvia verbenaca in addition to the essential oil of Cotula cinerea.


The obtained results raise then the possibility of a potential use of Cotula cinerea as a source of potent anticancer products.

Despite the appreciable advancements and progress made in cancer treatment, it continues to constitute a serious global health problem, especially with the appearance of multidrug resistance cells. Voucher specimens of both plants were deposited in the herbarium of the Botany Department of this institution.

Cabrera Cotula microglossa DC. Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. The sections possess different basic chromosome numbers:.

In the same conditions and for the Vero cell line, the best cytotoxic effect was observed with the essential oil followed by the hexane, the ethyl acetate, and the n -butanol extracts. Cineera, Volatile Search for additional papers on this topic.

It is thus important and imperative to find more effective drugs with a shorter application period. In the same conditions, higher concentrations were needed in the case of Salvia verbenaca extracts.

Comparative evaluation of antioxidant and insecticidal properties of essential oils from five Moroccan aromatic herbs. This was followed by the ethyl acetate extract cotuoa the essential cptula with moderate effects against RD cell ccotula and showed IC 50 values of References Publications referenced by this paper. Then, solvents of the different obtained extracts were evaporated and the dried residues were used to explore their cytotoxic effect.

Burtt Cotula reptans Benth. Most are disciform lacking ray florets. In the case of the RD cell line, the Fotula cinerea hexane extract showed the higher cytotoxic effect followed by the ethyl acetate, the essential oil, and the n -butanol extract.

These compounds could act individually or in a synergic manner.